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Welcome to Week 3 of Genomic and Precision Medicine! On this page, you will find the Week 3 learning outcomes, links to watch this week's lectures, and a description of this week's assignment.

Week 3 Learning Outcomes

This week, we will begin to explore the relationship among advances in DNA sequencing technology, genetic testing, and diagnosis. By the end of Week 3, students will begin to be able to:

• Summarize the concept of Whole Genome Analysis
• Describe the role of new sequencing technology
• Express the clinical significance of variants discovered through genetic testing
• Explore how new sequencing technologies are used to discover the genetic basis for puzzling, previously undiagnosed diseases
• Analyze practical issues surrounding genetic testing

Student Responsibilities and Deadlines

By the end of Week 3, students should:

• Watch all Week 3 Video Lectures
• Complete Week 3 Quiz (due by Monday, April 6, 9:00 AM Pacific time)
• Complete evaluation of Short Answer Peer Assessment #1 (due by Monday, April 6, 9:00 AM Pacific time)
• Complete evaluation of Short Answer Peer Assessment #2 (due by Monday, April 6, 9:00 AM Pacific time)

Detailed information on all these activities is provided below.

Video Lectures

Video	Slides (PDF)	Lecture Transcript/Subtitles (TXT)
Module 1: Whole Genome Analysis (12:39)	PDF	TXT
Module 2: Clinical interpretation of variants (17:51)	PDF	TXT
Module 3: Using NGS for diagnostic dilemmas (11:23)	PDF	TXT
Module 4: Practical Aspects (8:30)	PDF	TXT

Quiz

Each week, students will complete a multiple-choice quiz on the week's video lectures. Correct answers and scores are only revealed to students after the quiz has closed (multiple attempts are provided in case a student experiences technical errors or other problems with their initial attempt). The quiz for Week 3 is due at the end of Week 3 (Monday, April 6, by 9:00AM, Pacific Time). Quizzes can be found by clicking the "Quizzes" link in the left-hand navigation menu for this course.

Peer Assessment

There is no new Short Answer Peer Assessment this week.  However, students who submitted Week 1 and/or Week 2 Peer Assessments will be asked to evaluate the submissions of their peers.

Grading Week 1 and 2 Peer Assessments

Peer Assessments are made up of three phases: Submission, Evaluation, and Results. Now that the Submission phase has ended for Week 1 and 2, and students can no longer submit these first two assignments, students will enter the Evaluation phase and evaluate the work of their peers. In the Evaluation phase, you will return to the Peer Assessment section of the course (making sure to use a Coursera-supported browser), in order to review and score the work of your classmates. Using the grading rubric provided, select the appropriate score for your classmate's work from the dropdown menu displayed with each question.

In addition, please keep in mind that your classmates have a range of backgrounds, experiences, and skills, and that the goal of the peer assessment is NOT to be apply penalties if a student has issues with their writing structure or mechanics. Your primary goal as a grader is to determine whether your classmate made a genuine attempt to accurately reply to each question.

All students who completed the peer assessment are required to score at least five of their classmates' submissions. If you complete peer assessment evaluation for fewer than five of your classmates, your own assignment score will be deducted 20%. You are also invited to evaluate more than five of your classmates' work, but there is no additional credit for doing so. Your final score will be the median of all grades assigned by your classmates, and will be visible after the evaluation period ends on Monday, April 6, 9:00 AM Pacific Time. To grade the work of your peers, click the "Peer Assessments " link in the left-hand navigation menu of the course, then return to the Week 1 and 2 assignments by clicking the blue "Go to assignment " button for each.

Discussion Forums

In the Discussion Forums, students can introduce themselves, discuss assignments, report technical issues with the course, and talk about each week's video lectures. If you are just joining the class, please take a moment to introduce yourself to classmates in the Introductions forum. Each week of lectures has its own dedicated discussion forum; visit the Week 3 Lectures forum to discuss this week's video lectures and concepts.

Readings

As mentioned in the Syllabus, there is no required reading in this class.  However, we recommend that you check out "Genomic Medicine: A Decade of Successes, Challenges, and Opportunities", an article which highlights recent and future developments and obstacles in genetic research.  Also, if you are new to genetics or feel you need a lot of brushing up, we recommend that you review "The New Genetics", a booklet which covers foundational knowledge in genes and DNA as they pertain to healthcare.

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