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Welcome to Week 1 of Genomic and Precision Medicine! Please get started by reading the Course Overview/Syllabus for an outline of course expectations and requirements. On this page, you will find the Week 1 learning outcomes, links to watch this week's lectures, and a description of this week's assignment.

Week 1 Learning Outcomes

This week, we will be looking at the human genome structure, function, and variation. By peering into new insights into the structure of the human genome and different types of genetic and non-genetic variation that occur, we can lay a foundation that will improve our understanding of genomic and precision medicine as a whole. By the end of Week 1, students will begin to be able to:
  • Identify the structure of the human genome and how genes work
  • Describe structural variants
  • Explain mutations and single nucleotide variants
  • Summarize the consequences of single nucleotide variants in genes
  • Examine the architecture of human genome variation

Student Responsibilities and Deadlines

By the end of Week 1, students should:
  • Watch all Week 1 Video Lectures
  • Complete Week 1 Quiz (due by Monday, March 30, 9:00 AM Pacific time)
  • Complete Week 1 Peer Assessment (due by Monday, March 30, 9:00 AM Pacific time)
Detailed information on all these activities is provided below.

Video Lectures

Video Slides (PDF) Lecture Transcript/Subtitles (TXT)
Introduction and Module 1: The structure of the human genome and how things work (13:18)
PDF TXT
Module 2: Human genetic variation — structural variants (11:27)
PDF TXT
Module 3: Human genetic variation — single nucleotide variants (14:43)
PDF TXT
Module 4: Consequences of single nucleotide variants in genes (6:48)
PDF TXT
Module 5: Architecture of human genetic variation (14:46)
PDF TXT

Quiz

Each week, students will complete a multiple-choice quiz on the week's video lectures. Correct answers and scores are only revealed to students after the quiz has closed (multiple attempts are provided in case a student experiences technical errors or other problems with their initial attempt). These quizzes are usually due the week they are assigned; however, for Week 1, the quiz is not due until the end of Week 2 (Monday, March 30, 9:00 AM Pacific Time). Quizzes can be found by clicking the "Quizzes" link in the left-hand navigation menu for this course.

Peer Assessment

In addition to the multiple-choice quiz, students will complete one short answer question in the peer assessments section of the class. Like the quiz, this is due at the end of Week 2 (Monday, March 30, 9:00 AM Pacific Time). Detailed information may be found by clicking the "Peer Assessments" link in the left-hand navigation menu of the course.

Pre-Course Survey and Assessment

We would like students to fill out the Pre-Course Assessment (found in the Quizzes page) and UCSF pre-course survey.  While not mandatory, the assessment and survey will give you an opportunity to reflect on your purpose in this course, preview some of the topics that will be covered in this course, and provide the course team with information to better tailor the course and future Coursera offerings to its participants.

Discussion Forums

In the Discussion Forums, students can introduce themselves, discuss assignments, report technical issues with the course, and talk about each week's video lectures. Since this is the first week of the class, please take a moment to introduce yourself to classmates in the Introductions forum. Each week of lectures has its own dedicated discussion forum; visit the Week 1 Lectures forum to discuss this week's video lectures and concepts.

Readings

As mentioned in the Syllabus, there is no required reading in this class.  However, we recommend that you check out "Genomic Medicine: A Decade of Successes, Challenges, and Opportunities", an article which highlights recent and future developments and obstacles in genetic research.  Also, if you are new to genetics or feel you need a lot of brushing up, we recommend that you review "The New Genetics", a booklet which covers foundational knowledge in genes and DNA as they pertain to healthcare.

Created Tue 10 Dec 2013 10:19 PM CET
Last Modified Mon 16 Mar 2015 4:49 PM CET